Case Reports Int J Psychoanal -/- . 1989:70 ( Pt 3):461-79. Negative hallucinations, other irretrievable experiences and two functions of consciousness L W Brakel -/- PMID: 2793325 -/- Abstract -/- After providing a psychodynamic exploration of negative hallucinations in four clinical cases, the focus of this paper was broadened in an attempt to understand the mechanism of negative hallucination. To this end, after defining the term 'irretrievable experiences', two other examples--preconscious perceptions and infantile amnesia, both analogues to negative hallucination--were examined. (...) A discussion followed concerning two types of 'consciousness': 'consciousness' as a synonym for 'awareness' and 'consciousness' as a distinct psychological state. Next, the role of different functions of each sort of consciousness in the processes of conferring, fixing and retrieving mental contents within particular categories of experience was taken up. Finally, integrating developmental aspects of these same functions, explanations were offered regarding the mechanisms involved in preconscious perception, infantile amnesia and negative hallucinations. -/- PubMed. (shrink)

The role of the prefrontal cortex is one of the most topical and important areas of research in contemporary neuropsychology. This cortical region appears to be linked with executive processes affecting many diverse areas of cognitive function. Working memory, information processing, behavioural organization, attention, judgement, and the ability to cope with novel experiences are just some of the diverse processes it affects. This book brings together contributions from some of the world's leading researchers on the prefrontal cortex. They discuss the (...) many recent theoretical and technical advances in the field - for example in our understanding of the neural architecture of the prefrontal cortex, in the development of comparable texts of cognition in humans and other primates, in our understanding of the relationships between neuronal activity and behaviour, and in the increasing use of functional neuroimaging to identify different levels of organization within the prefrontal cortex. These important developments make this an ideal time to address the many questions and debates that have arisen about the role and functional organization of this area of the brain. One of the first books to be written on the subject, The Prefrontal Cortex is a state-of-the-art account of our knowledge of this exciting subject. It will be welcomed by all researchers and students in neuro- and cognitive psychology, and neuroscience. (shrink)

Recent preclinical studies have shown the feasibility of specific variants of nuclear transfer to prevent mitochondrial DNA disorders. Nuclear transfer could be a valuable reproductive option for carriers of mitochondrial mutations. A clinical application of nuclear transfer, however, would entail germ-line modification, more specifically a germ-line modification of the mitochondrial genome. One of the most prominent objections against germ-line modification is the fear that it would become possible to alter ‘essential characteristics’ of a future person, thereby possibly violating the child's (...) right to an open future. As only the nuclear DNA would contain the ingredients for individual characteristics, modification of the mtDNA is often considered less controversial than modification of the nuclear DNA. This paper discusses the tenability of this dichotomy. After having clarified the concept of germ-line modification, it argues that modification of the mtDNA is not substantively different from modification of the nuclear DNA in terms of its effects on the identity of the future person. Subsequently the paper assesses how this conclusion affects the moral evaluation of nuclear transfer to prevent mtDNA disorders. It concludes that the moral acceptability of germ-line modification does not depend on whether it alters the identity of the future child—all germ-line modifications do—but on whether it safeguards the child's right to an open future. If nuclear transfer to prevent mtDNA disorders becomes safe and effective, then dismissing it because it involves germ-line modification is unjustified. (shrink)

In the 21stcentury, there is a turn of thinking toward its reorientation first of all to the human as an author of thought and not to the nature, existing independently of us and of the process of scientific knowledge obtaining. It is possible to see the difference of these two types of thinking in the context of dialogue between W. Whewell’s philosophy and the scientific investigations after the scientific revolution in the beginning of the 20thcentury. In the philosophy of 21stcentury, (...) man is a social being and this is the basis of social philosophy. The artificial world around us is created by a human, it has its foundation in the laws of thinking but not the laws of nature. The foundations of both systems are quite different. In what way can we achieve mutual understanding between them? From both sides some aspects can be put forward, for instance, the concept of a mediator of a thought. This concept is studied actively by W. Whewell and by philosophers of our time, and this leads in both cases to some unexpected interpretation of the basic question of philosophy: the border between thing and thought is becoming less noticeable. We can come to the same result, going by different ways. Whewell finds common qualities for some group of things. Social philosophers are interested in what makes things different. Not one of these idealizations corresponds completely to the reality. Always something is not taken into consideration. A thinker chooses out of real world some of its characteristics that become a basis of a thought system, which explains everything but in its own way. The paper demonstrates the way of possible creation of a new type of thinking. (shrink)

There is growing interest in the use of technology to enhance the tracking and quality of clinical information available for patients in disaster settings. This paper describes the design and evaluation of the Wireless Internet Information System for Medical Response in Disasters (WIISARD).

I begin with Kant's notion of a maxim and consider the role which this notion plays in Kant's formulations of the fundamental categorical imperative. This raises the question of what a maxim is, and why there is not the same requirement for resolutions of other kinds to be universalizable. Drawing on Bernard Williams' notion of a thick ethical concept, I proffer an answer to this question which is intended neither in a spirit of simple exegesis nor as a straightforward exercise (...) in moral philosophy but as something that is poised somewhere between the two. My aim is to provide a kind of rational reconstruction of Kant. In the final section of the essay, I argue that this reconstruction, while it manages to salvage something distinctively Kantian, also does justice to the relativism involved in what J. L. Mackie calls 'people's adherence to and participation in different ways of life'. (shrink)